Concepedia
Cartilage · 2019 · 25 citations · 33 references
Open access
These results suggest that Sirt1 in human chondrocytes regulates autophagy by interacting with autophagy related Atg7, and Sirt1 may become a more important target in OA treatment.
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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
In Hye Lee, Liu Cao, Raúl Mostoslavsky et al. · Proceedings of the National Academy of Sciences · 2008 · 1.4K citations · Full text
Cell Autophagy, Mitophagy, Signal Transduction +15
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
Nirmala Hariharan, Yasuhiro Maejima, Jun Nakae et al. · Circulation Research · 2010 · 674 citations · Full text
Autophagy is a protective mechanism in normal cartilage, and its aging‐related loss is linked with cell death and osteoarthritis
B. Caramés, Noboru Taniguchi, Shuhei Otsuki et al. · Arthritis & Rheumatism · 2010 · 617 citations · Full text
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
Eugenia Morselli, Maria Chiara Maiuri, Maria Markaki et al. · Cell Death and Disease · 2010 · 595 citations · Full text
Mitophagy, Aging, Biogerontology +17
The Prevalence of Symptomatic Knee Osteoarthritis in China: Results From the China Health and Retirement Longitudinal Study
Xu Tang, Shengfeng Wang, Siyan Zhan et al. · Arthritis & Rheumatology · 2015 · 520 citations