The island of Gran Canaria: A genetic isolate for familial hypercholesterolemia

A simple salting out procedure for extracting DNA from human nucleated cells

S.A. Miller, Dale D. Dykes, Herbert F. Polesky · Nucleic Acids Research · 1988 · 20.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +8

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

Jian Ye, George Coulouris, Irena Zaretskaya et al. · BMC Bioinformatics · 2012 · 6.2K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +12

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society

Børge G. Nordestgaard, M. John Chapman, Steve E. Humphries et al. · European Heart Journal · 2013 · 2.7K citations · Full text

Medicine, Cardiology, Preventive Medicine +17

Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIA

Joseph L. Goldstein, Helmut G. Schrott, William R. Hazzard et al. · Journal of Clinical Investigation · 1973 · 1.5K citations · Full text

Medicine, Cardiology, Genetics +17

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

Claire Davis, Joseph L. Goldstein, Thomas C. Südhof et al. · Nature · 1987 · 407 citations

Life Sciences, Biochemistry, Molecular Biology +15