<p>A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor</p>

Abstract

<b>Background:</b> A silicon nanowire field effect transistor biosensor has four advantages in the detection of small biomolecules. It is mark-free, immediately responsive, highly sensitive, and specific. However, because of environments with a high salt concentration, the Debye screening effect has been a major issue in biological detection. <b>Objective:</b> To overcome Debye screening effect, realize the clinical application of silicon nanowire field effect transistor and verify its specificity and sensitivity. <b>Materials and methods:</b> The test solution was desalted by miniature blood dialyzer, and then the tumor markers were detected by silicon nanowire field effect transistor. <b>Results:</b> Tumor markers in serum were detected successfully and their sensitivity and specificity were verified. <b>Conclusion:</b> This method was found to effectively promote the development of semiconductor materials in biological solution detection.