BMC Infectious Diseases · 2019 · 30 citations · 10 references
Veterinary MedicineInfectious DiseasesPharmacotherapyHost-pathogen InteractionsImmunopharmacologyMycologyBacterial InfectionsFungal InfectionsFungal PathogenesisFungal PathologyInfectious PathologyOpportunistic Infection ManagementCryptococcal Infection TreatmentCryptococcal MeningitisFungal Infection TreatmentFungal MeningitisJanus Kinase Inhibitor TherapyJanus Kinase-signal Transducer And Activator Of Transcription SignalingJanus Kinase-stat Signaling ActivationOpportunistic Fungal Infections
BACKGROUND: Ruxolitinib is a highly potent janus kinase inhibitor that places its users at risk for various bacterial infections and viral reactivation. However new reports are also emerging that suggest greater immunosuppression and risk for fungal disease. CASE PRESENTATION: We report the case of a 51 year-old veteran from Guam, treated with ruxolitinib for polycythemia vera, who developed disseminated histoplasmosis and concurrent cryptococcal meningitis. CONCLUSION: This case draws attention to the degree of immunosuppression that may be seen with this drug and the need for heightened vigilance for opportunistic infections in those treated with inhibitors of janus kinase/signal transducers and activators of transcription (JAK/STAT) such as ruxolitinib.
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