Activation of the prostaglandin E₂ EP₂ receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices

Abstract

In conclusion, this study demonstrates that stimulation of the EP₂ receptor effectively mitigates renal fibrogenesis in various fibrosis models. These findings warrant further research into the clinical application of butaprost, or other EP₂ agonists, for the inhibition of renal fibrosis.