A New Macrodiolide and Two New Polycyclic Chromones from the Fungus Penicillium sp. SCSIO041218

Abstract

A new macrodiolide, mangrovlide A (<b>1</b>) and two new polycyclic chromones, penixanthones C (<b>2</b>) and D (<b>3</b>), as well as four other known compounds (<b>4</b>-<b>7</b>), have been isolated from the mangrove sediment derived fungus <i>Penicillium</i> sp. SCSIO041218, cultured in the 0.25% NaCl rice substrate. The structures of the new compounds were determined by analysis of the NMR and MS spectroscopic data. Compound <b>1</b> possesses a 10-membered macrodiolide unit, while <b>2</b> and <b>3</b> are chromones with an unprecedented 6/6/6/5 polycyclic skeleton. Compounds <b>1</b>-<b>7</b> were evaluated for their cytotoxicities, while all the compounds displayed weak or no activity.