A new efficient domino approach for the synthesis of coumarin-pyrazolines as antimicrobial agents targeting bacterial<scp>d</scp>-alanine-<scp>d</scp>-alanine ligase

Abstract

The inhibition of<sc>d</sc>-alanine-<sc>d</sc>-alanine ligase (Ddl) prevents bacterial growth, which makes this enzyme an attractive and viable target in the urgent search for novel effective antimicrobial drugs.