Second-Generation Histamine H1 Receptor Antagonists Suppress Delayed Rectifier K⁺-Channel Currents in Murine Thymocytes

Abstract

Our study revealed for the first time that second-generation antihistamines, including cetirizine, fexofenadine, azelastine, and terfenadine, exert suppressive effects on lymphocyte Kv1.3-channels. The efficacy of these drugs may be related to their immunomodulatory mechanisms that reduce the synthesis of inflammatory cytokine.