SUB-ACUTE TOXICITY STUDIES OF PARACETAMOL INFUSION IN ALBINO WISTAR RATS

Abstract

The objective of the present study was to evaluate the sub-acute toxicity of paracetamol infusion in albino wistar rats (male and female) at different dose levels, ranging from 16 to 66 mg/kg body weight. No mortality was seen in any of the treatment groups during the course of study. Various physiological, hematological as well as biochemical parameters were studied and found not to be changed significantly, indicating that paracetamol infusion is non toxic even at higher dose level in wistar rats. Overall safety and tolerability profile of paracetamol infusion is proved good and does not appear to carry risk of serious adverse effects.