Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine

Abstract

This study concludes that apical CaSR is active along the small intestine. Its activation by Ca²⁺ and/or calcimimetics reduces fluid secretion in a dose-dependent manner, with higher Ca²⁺ concentrations, or application of a calcimimetic, leading to fluid absorption. We furthermore show that, in the presence of FSK, receptor activation abates FSK secretagogue-induced fluid secretion. This presents a new therapeutic target to address secretory diarrheal illnesses.