Heterogeneity of red cell glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Egypt.

Abstract

Abstract Glucose-6-phosphate dehydrogenase (G-6-PD) was partially purified from blood of 52 Egyptian males and the variants characterized biochemically and electrophoretically. Subjects were from multiple geographic regions within Egypt. There were 18 abnormal variants plus the normal G-6-PD B+ (9 subjects). Previously described variants were G-6-PD's A+ (2), Ibadan-Austin (2), Debrousse (5), A- (1), Ramat-Gan (6), Athens-like (4), Mediterranean (3), Kabyle (2), Tel-Hashomer (3), Ohio (2), Chicago (1), Madrona (1), and West Bengal (1). Four new variants were characterized: G-6-PD's Tahta, Siwa, El-Kharga, and El-Fayoum. G-6-PD deficiency in Egypt, as elsewhere, is a heterogeneous defect.