Concepedia

Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure

Sandra Torres, Anna Baulies, Naroa Insausti-Urkia, Cristina Alarcón‐Vila, Raquel Fucho, Estel Solsona‐Vilarrasa, Susana Núñez, David Robles, Vicent Ribas, Leslie Wakefield,

Gastroenterology · 2019 · 135 citations · 40 references

DOIFull text

Open access

Abstract

In studies of mice, we found that upregulation of STARD1 following ER stress mediates APAP hepatoxicity via SH3BP5 and phosphorylation of JNK1 and JNK2.

References

40

ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE

J.R. Mitchell, David J. Jollow, William Z. Potter et al. · Journal of Pharmacology and Experimental Therapeutics · 1973 · 1.7K citations

Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice

Hisaya Azuma, Nicole K. Paulk, Aarati R. Ranade et al. · Nature Biotechnology · 2007 · 811 citations · Full text

, , +7

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

Jyoti Malhotra, Hongzhi Miao, Kezhong Zhang et al. · Proceedings of the National Academy of Sciences · 2008 · 663 citations · Full text

, , +14

Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily

Paul B. Watkins, Neil Kaplowitz, John T. Slattery et al. · JAMA · 2006 · 636 citations

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis

Francisca G. Caballero, Anna Colell, Albert Morales et al. · Cell Metabolism · 2006 · 594 citations · Full text

, , +16