Induction of Apoptosis and Inhibition of Invasion in Gastric Cancer Cells by Titanium Dioxide Nanoparticles

Abstract

OBJECTIVES: ) nanoparticles on apoptosis induction and invasion of gastric cancer cell line, MKN-45. METHODS: nanoparticles including amorph, brookite, anatase, and rutile coated with polyethylene glycol (PEG) and bovine serum albumin (BSA). Ethidium bromide and acridine orange staining were used to visualize cancer cell apoptosis, and the wound healing assay technique (migration test) was used to assay cancer cell invasion. RESULTS: ≤ 0.050). CONCLUSIONS: may provide a new strategy for cancer treatment and more studies are needed.