Harnessing¹³C-labeled<i>myo</i>-inositol to interrogate inositol phosphate messengers by NMR

Abstract

in HCT116 cells, especially in response to genetic and pharmacological perturbation. The reported method greatly facilitates the analysis of this otherwise spectroscopically silent group of molecules, and holds great promise to comprehensively analyze inositol-based signaling molecules under normal and pathological conditions.