Three new muurolane-type sesquiterpene glycosides from the whole plants of <i>Balanophora fungosa</i> subsp. <i>indica</i>

Abstract

Three new muurolane type sesquiterpene glycosides, named balanoindicosides A - C (<b>1 </b>-<b> 3</b>), were isolated from the whole plant of <i>Balanophora fungosa</i> subsp<i>. indica</i> using various chromatographic methods. Their structures were determined by extensive analysis of HR-ESI-MS and NMR spectroscopy. The stereochemistry of muurolane sesquiterpene backbone was demonstrated by NOESY analysis. Configuration of C-12 in compounds <b>2</b> and <b>3</b> could be distinguished by chemical shift value of C-14. Compounds <b>1</b>-<b>3</b> exhibited weak cytotoxic activity towards HepG-2, HL-60, LU-1, and MCF-7 cell lines.