Secondary metabolites produced by endophytic <i>Pantoea ananatis</i> derived from roots of <i>Baccharoides anthelmintica</i> and their effect on melanin synthesis in murine B16 cells

Abstract

Five indole derivatives, 1<i>H</i>-indol-7-ol (<b>1</b>), tryptophol (<b>2</b>), 3-indolepropionic acid (<b>3</b>), tryptophan (<b>4</b>), 3,3-di(1<i>H</i>-indol-3-yl)propane-1,2-diol (<b>5</b>) and two diketopiperazines, cyclo(L-Pro-L-Tyr) (<b>6</b>), cyclo[L-(4-hydroxyprolinyl)-L-leucine (<b>7</b>) along with one dihydrocinnamic acid (<b>8</b>) were isolated from <i>Pantoea ananatis</i> VERA8, that endophytic bacteria derived from <i>Baccharoides anthelmintica</i> roots. This is a first report towards an isolation of endophytic strains (funji or bacteria) from the <i>B. anthelmintica</i> herb. The synergetic properties of the total extract compositions, as well as effects of the pure isolated secondary metabolites evaluated on their melanin synthesis in murine B16 cells towards for vitiligo treatment.