Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type I

Abstract

We found that attention and CC volumes were reduced in participants with MPS I compared to typically developing controls. Smaller CC volumes in participants with MPS I were associated with decreased attention; such an association was not seen in controls. While hematopoietic cell transplantation used to treat MPS IH may compound these effects, attention difficulties were also seen in the MPS I_ATT group, suggesting that disease effects contribute substantially to the clinical attentional difficulties seen in this population.