Concepedia

Publication | Closed Access

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction

DOI

60

Citations

60

References

2019

Year

Julian Friebel, Alice Weithäuser, Marco Witkowski, Bernhard H. Rauch, Konstantinos Savvatis, Andrea Dörner, Termeh Tabaraie, Mario Kašner, Verena Moos, Diana Bösel,
European Heart Journal

Abstract

Protease-activated receptor 2 is an important regulator of profibrotic PAR1 and TGF-β signalling in the heart. Modulation of the FXa/FIIa-PAR1/PAR2/TGF-β-axis might be a promising therapeutic approach to reduce HFpEF.

References

YearCitations

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