TISIDB: an integrated repository portal for tumor–immune system interactions

TLDR

The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor‑immune interactions, we designed the user‑friendly web portal TISIDB, integrating multiple oncoimmunology data resources. We manually curated 4,176 records from 2,530 publications reporting 988 anti‑tumor immunity genes, identified genes linked to tumor resistance or sensitivity to T‑cell killing and immunotherapy via high‑throughput screening and genomic profiling, and pre‑calculated associations between genes and immune features for 30 TCGA cancer types. TISIDB enables biologists to cross‑check a gene’s role in tumor‑immune interactions through literature mining and high‑throughput data analysis, facilitating hypothesis generation and high‑quality figure creation for publication. Supplementary data are available at Bioinformatics online (http://cis.hku.hk/TISIDB).

Abstract

The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor-immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor-immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.http://cis.hku.hk/TISIDB.Supplementary data are available at Bioinformatics online.