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Enhanced Permeation of Methotrexate via Loading into Ultra-permeable Niosomal Vesicles: Fabrication, Statistical Optimization, Ex Vivo Studies, and In Vivo Skin Deposition and Tolerability

NanomedicineEngineeringTherapeutic NanomaterialsPharmaceutical NanotechnologyNano-drug DeliveryBiomedical EngineeringUltra-permeable Niosomal VesiclesDrug Delivery SystemVivo Skin DepositionEnhanced Permeation