Highly Efficient One‐Pot Three‐Component Synthesis and Antimicrobial Activity of 2‐Amino‐4<i>H</i>‐chromene Derivatives

Abstract

A remarkably efficient three‐component reaction to synthesize 2‐amino‐4 H ‐chromenes derivatives from malononitrile, various aromatic aldehydes, and orcinol was described at room temperature in CH 2 Cl 2 in the presence of catalytic amount of triethylamine. In a facile one‐pot procedure, excellent yields of products were achieved in less than 1 h. Some of the synthesized 2‐amino‐4 H ‐chromenes derivatives demonstrated potent antibacterial activities against Gram‐positive bacteria including Staphylococcus aureus and Bacillus anthracis , indicated by disk method, minimum inhibitory concentration, and minimum bactericidal concentration approaches. However, none of the tested compounds expressed any antibacterial activities against Enterococcus faecalis and Gram‐negative bacteria.