Green propolis extract promotes in vitro proliferation, differentiation, and migration of bone marrow stromal cells

Abstract

We have demonstrated that propolis extract was not toxic to BMMSCs (<400 μg/ml), supported their proliferation, potentiated chondrogenic and adipogenic differentiation processes, and supported cell migrationin vitro. Most interestingly, there was a down-regulation of osteogenesis. These data support the use of propolis extract for enhanced cell proliferation and tissue regeneration; however, it warrants further investigation.