Mucin binding to therapeutic molecules: The case of antimicrobial agents used in cystic fibrosis

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus <i>ex Vivo</i> and Distribution <i>in Vivo</i>

Qingguo Xu, Laura M. Ensign, Nicholas J. Boylan et al. · ACS Nano · 2015 · 554 citations

Pharmacy, Bioengineering, Pharmaceutics +17

Study of the interaction between icariin and human serum albumin by fluorescence spectroscopy

Guowen Zhang, Qingmin Que, Junhui Pan et al. · Journal of Molecular Structure · 2007 · 308 citations

Natural Sciences, Biochemistry, Chemistry +12

HT29‐MTX and Caco‐2/TC7 Monolayers as Predictive Models for Human Intestinal Absorption: Role of the Mucus Layer

Catherine Pontier, Jean I. Pachot, Roger P. Botham et al. · Journal of Pharmaceutical Sciences · 2001 · 148 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Mucin Binding Reduces Colistin Antimicrobial Activity

Johnny X. Huang, Mark A. T. Blaskovich, Ruby Pelingon et al. · Antimicrobial Agents and Chemotherapy · 2015 · 109 citations · Full text

Medicine, Pharmaceutics, Pharmacology +15

A small molecule CFTR inhibitor produces cystic fibrosis‐like submucosal gland fluid secretions in normal airways

Jay R. Thiagarajah, Yuanlin Song, Peter M. Haggie et al. · The FASEB Journal · 2004 · 107 citations · Full text

Medicine, Pharmacology, Membrane Trafficking +9