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2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2

Ros AccumulationApoptosisCell DeathSumoylation InhibitorAnti-cancer AgentReactive Oxygen SpecieRadiation OncologyMedicineCell BiologyCell SignalingOxidative StressMyeloid Neoplasia