Differential clinical significance of <scp>COL</scp>5A1 and <scp>COL</scp>5A2 in tongue squamous cell carcinoma

Abstract

COL5A1 is an unfavorable factor for tumorigenesis, clinicopathological outcomes, and prognosis, whereas COL5A2 is only a favorable factor for prognosis in TSCC. The co-expression of high (COL5A1)2/low (COL5A2) heterotrimer is a more potential unfavorable factor for prognosis in TSCC.