Theranostics · 2019 · 81 citations · 39 references
MedicinePharmacokineticsPharmacologyCancer PharmacologyCircadian RhythmsMolecular OncologyCircadian Clock MechanismsCircadian Molecular MechanismsCircadian Regulation Of MetabolismDrug DispositionGastrointestinal PharmacologyIntestinal Drug MetabolismCell Viability AssaysChemotherapeutic EffluxCircadian OscillationIntestinal Drug EffluxIntestinal Efflux TransportersLuciferase Reporter AssaysLuciferase ReportersMultidrug Resistance-associated Protein-mediated Efflux
The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range of drugs. Here, we aimed to clarify the impact of circadian clock on intestinal MRP2, and to determine the molecular mechanisms for generation of diurnal MRP2 expression.
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