The evolution of proteome: From the primeval to the very dawn of LUCA

Basic local alignment search tool

Stephen F. Altschul, Warren Gish, Webb Miller et al. · Journal of Molecular Biology · 1990 · 94.5K citations

Life Sciences, Bioinformatics, Sequence Analysis +3

UCSF Chimera—A visualization system for exploratory research and analysis

Eric F. Pettersen, Thomas D. Goddard, Conrad C. Huang et al. · Journal of Computational Chemistry · 2004 · 47.8K citations

Computing, Bioinformatics, Visualization +17

I-TASSER server for protein 3D structure prediction

Yang Zhang · BMC Bioinformatics · 2008 · 5.2K citations · Full text

Life Sciences, Bioinformatics, Biology +10

The COG database: an updated version includes eukaryotes

Roman L. Tatusov, Natalie D. Fedorova, John D. Jackson et al. · BMC Bioinformatics · 2003 · 4.5K citations · Full text

Life Sciences, Biology, Evolutionary Biology +14

TM-align: a protein structure alignment algorithm based on the TM-score

Yang Zhang · Nucleic Acids Research · 2005 · 4K citations · Full text

Life Sciences, Biochemistry, Bioinformatics +15