Beta-Boswellic Acid and Ethanolic Extract of Olibanum Regulating the Expression Levels of <i>CREB-1</i> and <i>CREB-2</i> Genes.

Abstract

gene expression levels in time-dependent but not in dose-dependent way. However, β-BA showed stronger and more stable effects. The expression levels of the both genes followed an alternate upregulation and downregulation pattern, but in opposite directions, in response to the both solutions with the progress of time. These results suggest that Olibanum possibly improves memory performance, at least partially, by regulating the levels of CREB-1 and CREB-2 transcription factors via positive/negative-feedback loops.