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Prediction of Ticagrelor and its Active Metabolite in Liver Cirrhosis Populations Using a Physiologically Based Pharmacokinetic Model Involving Pharmacodynamics

HepatologyPharmacokinetic ModelingMedicineLiver PhysiologyPhysiologyHepatitisToxicologyPharmacotherapyAcute Liver FailureLiver Cirrhosis PopulationsActive MetaboliteMetabolomicsHepatotoxicityPharmacologyLiver DiseaseDrug-induced Liver InjuryPharmacokineticsHealth Sciences