Publication | Closed Access
Immobilization of<scp>l</scp>-methioninase on a zirconium-based metal–organic framework as an anticancer agent
23
Citations
48
References
2019
Year
Pharmaceutical ScienceOrganic ChemistryChemistryPharmaceutical ChemistryAnticancer AgentInorganic CompoundMolecular PharmacologyMedicinal ChemistryEnhanced ThermostabilityMetal-organic PolyhedronInorganic ChemistryBiochemistryTumor GrowthPharmacologyZirconium-based Metal–organic FrameworkBiomolecular EngineeringNatural SciencesNew CompositeBioactive MetalMedicineDrug Discovery
A new composite (METase@UiO-66) was prepared from<sc>l</sc>-methioninase and UiO-66-(COOH), which exhibited enhanced thermostability, pH and storage lifetime compared to<sc>l</sc>-methioninase. Moreover,<italic>in vivo</italic>experiments showed that the drug inhibited tumor growth in mice.
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