VU0810464, a non‐urea G protein‐gated inwardly rectifying K⁺ (K_ir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K_ir3 channels and reduces stress‐induced hyperthermia in mice

Abstract

VU0810464 represents a new class of K_ir 3 channel activator with enhanced selectivity for K_ir 3.1/3.2 channels. VU0810464 may be useful for examining K_ir 3.1/3.2 channel contributions to complex behaviours and for probing the potential of K_ir 3 channel-dependent manipulations to treat neurological disorders.