Rare Missense Variants in <i>TLN1</i> Are Associated With Familial and Sporadic Spontaneous Coronary Artery Dissection

Abstract

Our findings reveal TLN1 as a disease-associated gene in familial and sporadic SCAD and, together with abnormal vascular phenotypes reported in animal models of talin 1 disruption, implicate impaired structural integrity of the coronary artery cytoskeleton in SCAD susceptibility.