Expeditious and highly efficient synthesis of propargylamines using a Pd‐Cu nanowires catalyst under solvent‐free conditions

Abstract

A heterogeneous Pd‐Cu NWs‐catalyzed expeditious and solvent‐free synthesis of propargylamines via A 3 ‐coupling of aldehydes, alkynes, and amines has been proposed. A wide range of aldehydes, alkynes and amine substrates undergo A 3 ‐coupling to produce propargylamines in good to excellent yields with good functional tolerance, such as that towards alkoxy, hydroxy, C‐X (X = F, Cl, Br) as well as amide and C=C bonds. Furthermore, the catalyst could be recovered easily and reused for at least 5 cycles without showing significant loss of catalytic activity.