Calcium Release from Endoplasmic Reticulum Involves Calmodulin-Mediated NADPH Oxidase-Derived Reactive Oxygen Species Production in Endothelial Cells

Abstract

BK-induced NOX-derived ROS production was mediated via a Ca²⁺/CaM-dependent pathway; however, it was independent from NOX phosphorylation. This was strictly regulated by ER Ca²⁺ contents.