Asian Journal of Chemical Sciences · 2019 · 14 citations · 0 references
Natural SciencesChemistryBioorganic ChemistryInorganic ChemistryStructure-activity RelationshipsCoordination ChemistryLigand BindingMetal-ligand BondingStructure-activity Relationship AnalysisTransition Metal ChemistryTransition Metal ComplexesBioinorganic Coordination ChemistryComplexation ChemistryConductivityCoordinationEscherichia ColiIntermolecular Metal-ligand InteractionsMetal Ligand CoordinationSpectroscopic Characterization Of Metal-ligand Bonds
Two complexes of Cu(II) and Ni(II) with the ligand N- (4-methoxybenzylidene) isonicotinohydrazide, having the formula [M(La)2]2+ (M = Cu(II) and Ni(II)) were synthesized. The ligand was synthesized by the condensation of isonicotinic acid hydrazide (isoniazid) with 4- methoxybenzaldehyde (p- anisaldehyde). The complexes were characterized by FTIR, UV-Vis spectroscopy, molar conductivity, magnetic susceptibility and evaluated for their in vitro antibacterial activity against human pathogens like gram negative Escherichia coli (E. coli) and gram positive Bacillus cereus (B. cereus)strains. The results indicate that all complexes consist of N and O coordination with metals has better antimicrobial activity.