<p>The role of long non-coding RNA GAS5 in cancers</p>

Abstract

Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing either oncogenic or tumor suppressive roles. Emerging evidences have proved that the growth arrest-specific 5 (<i>GAS5</i>) lncRNA can function as a tumor suppressor in several cancers. LncRNA <i>GAS5</i> is downregulated in many types of cancer, regulating cellular processes such as cell proliferation, apoptosis and invasion. The low level of <i>GAS5</i> expression often elevates capacity of proliferation and predicts poorer prognosis in some cancers. This review aims to summarize the recent published literature on the biogenesis, regulation mechanism and function of <i>GAS5</i> in different types of cancers and explore its potential for cancer diagnosis, prognosis and treatment.