Concepedia

Lipid membranes accelerate amyloid formation in the mouse model of AA amyloidosis

Aida Vahdat Shariat Panahi, Per Hultman, Karin Öllinger, Gunilla T. Westermark, Katarzyna Lundmark

Amyloid · 2019 · 19 citations · 31 references

DOIFull text

Open access

Abstract

We conclude that increased intracellular lipid content facilitates AA amyloid fibril formation and show that the mouse model of AA amyloidosis is a suitable system for further mechanistic studies.

References

31

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F4/80, a monoclonal antibody directed specifically against the mouse macrophage

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Seth L. Masters, Aisling Dunne, Shoba Subramanian et al. · Nature Immunology · 2010 · 1.3K citations · Full text

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Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines

Jean D. Sipe, Merrill D. Benson, Joel N. Buxbaum et al. · Amyloid · 2016 · 589 citations

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Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

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, , +19