Mild cognitive impairment in de novo Parkinson's disease: A neuromelanin MRI study in locus coeruleus

Abstract

Dysfunction of the locus coeruleus neurons may partly contribute to the decline in executive function in early de novo PD. In the future, the locus coeruleus-norepinephrine system might be targeted for early-intervention strategies in PD patients. © 2019 International Parkinson and Movement Disorder Society.