Design, Synthesis of Some New Thio-Substituted Imidazole and Their Biological Activity

Abstract

In an attempt to find a new class of antimicrobial and antioxidant agents, a two new series of S-alkyl-imidazolidin-4-one(3a,b-5) and S-alkyl-imidazole 13a-d,15a-e,16,17a,b and 25a-d were prepared. Their antioxidant potential were evaluated using DPPH (1,1-diphenyl-2-picrylhydrazyl) radical method in vitro. Their antibacterial screening against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeuroginosa and Escherichia coli and antifungal activity against Aspergillus fumigates, Syncephalastrum racemosum, Geotrichum candidum and Candida albicans were also evaluated, most of the compounds showed to potent and significant results when compared to the respective standards. Structures of the newly synthesized compounds were established by elemental analysis and spectral data.