Progress in Copper-Catalyzed Chan-Lam Coupling of N-Compounds

Abstract

Construction of C-N bond is one of the most important areas in synthetic organic chemistry and medical chemistry. Many synthetic methods for the construction of C-N bond have been reported over the past few years. Copper-catalyzed Chan-Lam reactions represent one of the most powerful and straightforward tools to construct C-N bonds. In this paper, the recent progress in Chan-Lam coupling of N-compounds with (hetero)aryl boronates to construct C-N bond based on the reaction mechanism, reaction system, the scope of substrates, etc., is reviewed.