Design of novel Surfactant Modified Carbon Nanotube PasteElectrochemical Sensor for the Sensitive Investigation of Tyrosineas a Pharmaceutical Drug

Abstract

<b><i>Purpose:</i></b> The novel sodium dodecyl sulfate modified carbon nanotube paste electrode (SDS/ CNTPE) was used as a sensitive sensor for the electrochemical investigation of L-tyrosine (TY). <b><i>Methods:</i></b> The electrochemical analysis of TY was displayed through cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The surface morphology of SDS/CNTPE and bare carbon nanotube past electrode (BCNTPE) was reviewed trough field emission scanning electron microscopy (FESEM). <b><i>Results:</i></b> The functioning SDS/CNTPE shows a voltammetric response with superior sensitivity towards TY. This study was conducted using a phosphate buffer solution having neutral pH (pH=7.0). The correlation between the oxidation peak current of TY and concentration of TY was achieved linearly in CV method, in the range 2.0×10^-6 to 5 ×10^-5 M with the detection limit 729 nM and limit of quantification 2.43 μM. The investigated voltammetric study at SDS/CNTPE was also adopted in the examination of TY concentration in a pharmaceutical medicine as a real sample with the recovery of 97% to 98% . <b><i>Conclusion:</i></b> The modified electrode demonstrates optimum sensitivity, constancy, reproducibility, and repeatability during the electrocatalytic activity of TY.