Regulation of P-glycoprotein by Bajijiasu <i>in vitro</i> and <i>in vivo</i> by activating the Nrf2-mediated signalling pathway

Abstract

BJJS activates Nrf2 to induce P-gp expression, and enhanced the efflux activity of P-gp. The possibility of potential herb-drug interactions when BJJS is co-administered with other P-gp substrate drugs should be carefully monitored.