Concepedia

Inhibiting the stringent response blocks <i>Mycobacterium tuberculosis</i> entry into quiescence and reduces persistence

Noton K. Dutta, Lee G. Klinkenberg, Maria-Jesus Vazquez, Delfina Segura-Carro, Gonzalo Colmenarejo, Fernando Ramón, Beatriz Rodríguez-Miquel, Lydia Mata-Cantero, Esther Porras-De Francisco, Yu-Min Chuang,

Science Advances · 2019 · 134 citations · 54 references

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Abstract

The stringent response enzyme is a promising new target for Mycobacterium tuberculosis persisters.

References

54

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

Kyle R. Allison, Mark P. Brynildsen, James J. Collins · Nature · 2011 · 1K citations · Full text

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Molecular Mechanisms Underlying Bacterial Persisters

Etienne Maisonneuve, Kenn Gerdes · Cell · 2014 · 643 citations · Full text

, , +12

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating <i>Mycobacterium tuberculosis</i>

Srinivasa P. S. Rao, Sylvie Alonso, Lucinda Rand et al. · Proceedings of the National Academy of Sciences · 2008 · 536 citations · Full text

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Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response

César de la Fuente‐Núñez, Fany Reffuveille, Evan F. Haney et al. · PLoS Pathogens · 2014 · 516 citations · Full text

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The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

Gemma C. Atkinson, Tanel Tenson, Vasili Hauryliuk · PLoS ONE · 2011 · 459 citations · Full text

, , +15