Activation of K<sub>v</sub>7 channels as a novel mechanism for NO/cGMP‐induced pulmonary vasodilation - Concepedia

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Publication | Open Access

Activation of K<sub>v</sub>7 channels as a novel mechanism for NO/cGMP‐induced pulmonary vasodilation

DOI Full Paper Access

28

Citations

48

References

2019

Year

Gema Mondéjar‐Parreño, Javier Moral‐Sanz, Bianca Barreira, Alicia de la Cruz, Teresa González, María Callejo, Sergio Esquivel‐Ruiz, Daniel Morales‐Cano, Laura Moreno, Carmen Valenzuela,

British Journal of Pharmacology

Abstract

NO donors and riociguat enhance K<sub>v</sub> 7 currents, leading to PASMC hyperpolarization. This mechanism contributes to NO/cGMP-induced PA vasodilation. Our study identifies K<sub>v</sub> 7 channels as a novel mechanism of action of vasodilator drugs used in the treatment of pulmonary arterial hypertension.

References

	Year	Citations

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