Concepedia

Inhibition of phosphodiesterase‐4 attenuates murine ulcerative colitis through interference with mucosal immunity

Heng Li, Fan Chen, Chunlan Feng, Yanwei Wu, Huimin Lu, Pei‐Lan He, Xiaoqian Yang, Fenghua Zhu, Qing Qi, Yuanzhuo Gao,

British Journal of Pharmacology · 2019 · 92 citations · 26 references

DOIFull text

Open access

Abstract

Inhibition of PDE4 by apremilast protected against UC, by interfering with mucosal immunity. These findings represent a promising strategy for regulating intestinal inflammation.

References

26

Animal research: Reporting <i>in vivo</i> experiments: The ARRIVE guidelines

Carol Kilkenny, William J. Browne, Innes C. Cuthill et al. · British Journal of Pharmacology · 2010 · 3.6K citations · Full text

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Animal Research: Reporting <i>in vivo</i> Experiments—The ARRIVE Guidelines

Carol Kilkenny, William J. Browne, Innes C. Cuthill et al. · Journal of Cerebral Blood Flow & Metabolism · 2011 · 2K citations · Full text

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Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice

Benoît Chassaing, J D Aitken, Madhu Malleshappa et al. · Current Protocols in Immunology · 2014 · 2K citations

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

Simon D Harding, Joanna L Sharman, Elena Faccenda et al. · Nucleic Acids Research · 2017 · 1.6K citations · Full text

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Chemically induced mouse models of acute and chronic intestinal inflammation

Stefan Wirtz, Vanessa Popp, Markus Kindermann et al. · Nature Protocols · 2017 · 1.4K citations

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