Reductive Bromodifluoromethylation of Nitrones Promoted by Visible Light

Abstract

A method for the synthesis of bromodifluoromethyl‐substituted hydroxylamines via reaction of nitrones with dibromodifluoromethane is described. The reaction is mediated by an iridium photocatalyst activated by blue light and employs ascorbic acid as a reductant. In the products, the bromodifluoromethyl fragment can be reduced to the CHF 2 ‐group or can be functionalized through the hydrofluoroalkylation process.