Phenyliodonium Diacetate Mediated Carbotrifluoromethylation of Quinoxalin‐2(1<i>H</i>)‐ones

Abstract

Abstract An efficient method for the synthesis of 3‐trifluoromethylquinoxalin‐2(1 H )‐ones by a direct trifluoromethylation of quinoxalin‐2(1 H )‐one derivatives has been developed under transition‐metal‐free conditions. The strategy uses cheap and commercially available PhI(OAc) 2 as a promoter, TMSCF 3 as a trifluoromethylation reagent in the presence of catalytic amount of benzoquinone to give the products in good yields.