<i>KLOTHO</i> heterozygosity attenuates <i>APOE4</i> -related amyloid burden in preclinical AD

Abstract

In a cohort of at-risk late-middle-aged adults, KL-VS heterozygosity was associated with an abatement of <i>APOE4-</i>associated Aβ aggregation, suggesting KL-VS heterozygosity confers protections against <i>APOE4-</i>linked pathways to disease onset in AD.