Novel <scp>CSF</scp> biomarkers in genetic frontotemporal dementia identified by proteomics

Abstract

We identified and validated five novel CSF biomarkers in <i>GRN-</i>associated FTD. Our results show that synaptic, secretory vesicle, and inflammatory proteins are dysregulated in the symptomatic stage and may provide new insights into the pathophysiology of genetic FTD. Further validation is needed to investigate their clinical applicability as diagnostic or monitoring biomarkers.