American Journal of Clinical Pathology · 2019 · 68 citations · 14 references
MedicineOncologyPathologyCytopathologySalivary DiagnosticsSalivary Gland DisordersSalivary Gland BiopsySalivary Gland CancerSalivary Gland CytologySalivary Gland MalignanciesSalivary Gland PathologySalivary GlandsAtypia Of Undetermined SignificanceBenign DiagnosisMalignant Salivary Gland LesionsSalivary Gland Cytology ReportingSalivary Gland Fine-needle Aspiration CytologySalivary Gland Lesion ClassificationSalivary Gland Tumor CytologySalivary Gland Tumor Diagnosis
OBJECTIVES: Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). METHODS: A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Risk of malignancy (ROM) for each category was calculated based on 694 histologic follow-up cases. RESULTS: The ROM for each category was: 18.3% for nondiagnostic, 8.9% for nonneoplastic, 37.5% for atypia of undetermined significance (AUS), 2.9% for benign neoplasm, 40.7% for salivary gland neoplasm of uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 98.3% for malignant. The sensitivity, specificity, positive predictive rate, and negative predictive rates were 89%, 99%, 98%, and 96%, respectively. CONCLUSIONS: The results of the current study are in keeping with the MSRSGC. The indeterminate categories of AUS and SUMP showed intermediate ROMs at 37.5% and 40.7%, respectively.
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Esther Diana Rossi, Lawrence Q. Wong, Tommaso Bizzarro et al. · Cancer Cytopathology · 2016 · 144 citations · Full text